Article
Polymorphisms near IL28B and serologic response to peginterferon in HBeAg-positive patients with chronic hepatitis B.
Gastroenterology - 1 Mar 2012
Sonneveld Milan J, Wong Vincent W-S, Woltman Andrea M, Wong Grace L H, Cakaloglu Yilmaz, Zeuzem Stefan, Buster Erik H C J, Uitterlinden Andre G, Hansen Bettina E, Chan Henry L Y, Janssen Harry L A
Abstract excerpt
BACKGROUND & AIMS: A limited number of patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B respond to treatment with peginterferon alfa (PEG-IFN). We investigated whether IL28B genotypes are associated with response. METHODS: We studied 205 HBeAg-positive patients who were treated with PEG-IFN (some were also treated with lamivudine) at 11 European and Asian hospitals; genotype analysis was...
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