Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of Gut-Targeted 15-LOX-1 Transgene Expression on Colonic Tumorigenesis in Mice

2 Apr 2012

Abstract excerpt

Expression of 15-lipoxygenase-1 (15-LOX-1) is decreased in many human cancers; however, the mechanistic significance of its decreased expression has been difficult to determine because its mouse homolog 12/15-LOX has opposing functions. We generated a mouse model in which expression of a human 15-LOX-1 transgene was targeted to the intestinal epithelium via the villin promoter. Targeted expression was confirmed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioactive Compounds and Antitumor Agents
Share to Inflammatory mediators and NSAID effects
Share to Veterinary medicine and infectious diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22472308
DOI: 10.1093/jnci/djs187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of Gut-Targeted 15-LOX-1 Transgene Expression on Colonic Tumorigenesis in MicePMID 22472308Read ↗

A new conditional Apc-mutant mouse model for colorectal cancer.Semantic proximity Read ↗

Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia.Semantic proximity Read ↗

Loss of GDF-15 abolishes sulindac chemoprevention in the ApcMin/+ mouse model of intestinal cancer.Semantic proximity Read ↗

The transcription factor GATA‐6 is overexpressed <i>in vivo</i> and contributes to silencing 15‐LOX‐1 <i>in vitro</i> in human colon cancerSemantic proximity Read ↗

NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory ResponseSemantic proximity Read ↗

15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.Semantic proximity Read ↗

Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model.Semantic proximity Read ↗

MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors.Semantic proximity Read ↗

Non‐canonical WNT5A signaling up‐regulates the expression of the tumor suppressor 15‐PGDH and induces differentiation of colon cancer cellsSemantic proximity Read ↗

Knockout of the 15 kDa Selenoprotein Protects against Chemically-Induced Aberrant Crypt Formation in MiceSemantic proximity Read ↗

Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.Semantic proximity Read ↗

Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.