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The transcription factor GATA‐6 is overexpressed <i>in vivo</i> and contributes to silencing 15‐LOX‐1 <i>in vitro</i> in human colon cancer

13 Dec 2006

Abstract excerpt

Transcriptional suppression of 15-lipoxygenase (LOX)-1 (15-LOX-1) helps enable human colorectal cancer cells escape apoptosis, a critical mechanism for colonic tumorigenesis. GATA-6 is strongly expressed in vitro in cancer cells; its down-regulation by pharmaceuticals is associated with reversal of 15-LOX-1 transcriptional suppression. The mechanistic contribution of GATA-6 overexpression to colonic...

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PMID: 17167069
DOI: 10.1096/fj.06-6830com

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