Article
MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors.
Gastroenterology - 1 Feb 2018
Liu Ronghua, Lu Zhou, Gu Jie, Liu Jiajing, Huang Enyu, Liu Xiaoming, Wang Luman, Yang Jiao, Deng Yuting, Qian Jiawen, Luo Feifei, Wang Zhiming, Zhang Hushan, Jiang Xuechao, Zhang Dan, Qian Jing, Liu Guangwei, Zhu Hongguang, Qian Youcun, Liu Zhanju, Chu Yiwei
Abstract excerpt
BACKGROUND & AIMS: B cells infiltrate tumors, but little is known about how they affect tumor growth and progression. microRNA15A (MIR15A or miRNA15A) and microRNA16-1 (MIR16-1 or miRNA16-1) regulate cell proliferation, apoptosis, and drug resistance. We investigated their involvement in B-cell-mediated immune suppression by colorectal tumors. METHODS: Mice with disruptions of the gene cluster that encodes MIR15A...
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