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Article

Loss of GDF-15 abolishes sulindac chemoprevention in the ApcMin/+ mouse model of intestinal cancer.

Journal of cancer research and clinical oncology - 1 Apr 2010

Zimmers Teresa A, Gutierrez Juan C, Koniaris Leonidas G

Abstract excerpt

BACKGROUND: Growth-differentiation factor (GDF)-15, a member of the TGF-beta superfamily, is potently induced in the intestine following mechanical injury, genotoxic insult and following non-steroidal anti-inflammatory drugs (NSAIDs) exposure. GDF-15 expression correlates with apoptosis in intestinal cells and has been implicated in the pathogenesis of colorectal cancer formation and the anti-tumor effects of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19784846
DOI: 10.1007/s00432-009-0691-4

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