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Article

15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.

International journal of cancer - 15 Dec 2008

Zhu Hong, Glasgow Wayne, George Margaret D, Chrysovergis Kali, Olden Kenneth, Roberts John D, Eling Thomas

Abstract excerpt

15-LOX-1 and its metabolites are involved in colorectal cancer. Recently, we reported that 15-LOX-1 overexpression in HCT-116 human colorectal cancer cells inhibited cell growth by induction of p53 phosphorylation (4). To determine whether the 15-LOX-1 protein or its metabolites are responsible for phosphorylation of p53 in HCT-116 cells, we used HCT-116 cells that expressed a mutant 15-LOX-1. The mutant 15-LOX-1...

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Identifiers

PMID: 18785202
DOI: 10.1002/ijc.23855
PMCID: PMC2613223

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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