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Article

A new conditional Apc-mutant mouse model for colorectal cancer.

Carcinogenesis - 1 May 2010

Robanus-Maandag Els C, Koelink Pim J, Breukel Cor, Salvatori Daniela C F, Jagmohan-Changur Shantie C, Bosch Cathy A J, Verspaget Hein W, Devilee Peter, Fodde Riccardo, Smits Ron

Abstract excerpt

Mutations of the adenomatous polyposis coli (APC) gene predispose individuals to familial adenomatous polyposis (FAP), characterized by multiple tumours in the large intestine. Most mouse models heterozygous for truncating mutant Apc alleles mimic FAP, however, the intestinal tumours occur mainly in the small intestine. To model large intestinal tumours, we generated a new conditional Apc-mutant allele,...

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Identifiers

PMID: 20176656
DOI: 10.1093/carcin/bgq046

Genes

FAP
APC

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