Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

doi:10.1128/mcb.10.12.6742-6754.1990

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Article

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Dec 1990

Herman P K, Emr S D

Abstract excerpt

VPS34 gene function is required for the efficient localization of a variety of vacuolar proteins. We have cloned and sequenced the wild-type VPS34 gene in order to gain a better understanding of the role of its protein product in this intracellular sorting pathway. Interestingly, disruption of the VPS34 locus resulted in a temperature-sensitive growth defect, indicating that the VPS34 gene is essential for...

Topics

Amino Acid Sequence
Base Sequence
Chromosome Deletion
DNA, Fungal
Escherichia coli
Fungal Proteins
Genes, Fungal
Genetic Vectors
Genotype
Molecular Sequence Data
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Polymerase Chain Reaction

Protein Conformation

Restriction Mapping

Saccharomyces cerevisiae

Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 2247081
DOI: 10.1128/mcb.10.12.6742-6754.1990
PMCID: PMC362952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2247081-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.PMID 2247081Read ↗

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