Article
The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment.
Current genetics - 1 Jun 1997
Finken-Eigen M, Röhricht R A, Köhrer K
Abstract excerpt
Four yeast mutants were isolated in a screen for dominant-negative vacuolar protein-sorting mutants, secreting a carboxypeptidase Y-invertase hybrid protein. In addition to defects in the sorting/transport of soluble vacuolar hydrolases, the mutants accumulated a pre-vacuolar endosome-like compar...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Biological Transport
- Carboxypeptidases
- Cathepsin A
- Cell Compartmentation
- Endocytosis
- Endosomal Sorting Complexes Required for Transport
- Endosomes
- Fungal Proteins
- Genes, Dominant
- Genetic Complementation Test
- Glycoside Hydrolases
- Golgi Apparatus
- Hydrolases
- Molecular Sequence Data
- Mutation
- Open Reading Frames