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Article

PER3 polymorphism and insomnia severity in alcohol dependence.

Sleep - 1 Apr 2012

Brower Kirk J, Wojnar Marcin, Sliwerska Elzbieta, Armitage Roseanne, Burmeister Margit

Abstract excerpt

STUDY OBJECTIVES: Insomnia is common, persistent, and associated with relapse in alcohol-dependent (AD) patients. Although the underlying mechanisms are mostly unstudied, AD patients have impaired circadian rhythms and sleep drive, which may be genetically influenced. A polymorphism in the PER3 gene (PER3(4/4), PER3(4/5), PER3(5/5)) has previously been associated with circadian preference and sleep homeostasis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22467995
DOI: 10.5665/sleep.1748
PMCID: PMC3296799

Genes

PER3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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