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Article

A promoter polymorphism in the Per3 gene is associated with alcohol and stress response.

Translational psychiatry - 31 Jan 2012

Wang X, Mozhui K, Li Z, Mulligan M K, Ingels J F, Zhou X, Hori R T, Chen H, Cook M N, Williams R W, Lu L

Abstract excerpt

The period homolog genes Per1, Per2 and Per3 are important components of the circadian clock system. In addition to their role in maintaining circadian rhythm, these genes have been linked to mood disorders, stress response and vulnerability to addiction and alcoholism. In this study, we combined high-resolution sequence analysis and quantitative trait locus (QTL) mapping of gene expression and behavioral traits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22832735
DOI: 10.1038/tp.2011.71
PMCID: PMC3309544

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