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Article

Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence.

Human genetics - 1 Oct 2013

Seneviratne Chamindi, Franklin Jason, Beckett Katherine, Ma Jennie Z, Ait-Daoud Nassima, Payne Thomas J, Johnson Bankole A, Li Ming D

Abstract excerpt

On the basis of the converging evidence showing regulation of drinking behavior by 5-HT3AB receptors and the serotonin transporter, we hypothesized that the interactive effects of genetic variations in the genes HTR3A, HTR3B, and SLC6A4 confer greater susceptibility to alcohol dependence (AD) than do their effects individually. We examined the associations of AD with 22 SNPs across HTR3A, HTR3B, and two...

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Identifiers

PMID: 23757001
DOI: 10.1007/s00439-013-1319-y
PMCID: PMC3775919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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