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Article

The relationship between alcohol- and sleep-related traits: Results from polygenic risk score and Mendelian randomization analyses.

Drug and alcohol dependence - 1 Oct 2023

Chakravorty Subhajit, Kember Rachel L, Mazzotti Diego R, Dashti Hassan S, Toikumo Sylvanus, Gehrman Philip R, Kranzler Henry R

Abstract excerpt

STUDY OBJECTIVES: We investigated whether genetic risk for insomnia and sleep duration abnormalities are associated with AUD and alcohol consumption. We also evaluated the causal relationships between sleep- and alcohol-related traits. METHODS: Individual-level phenotype and genotype data from the Million Veteran Program were used. Polygenic risk scores (PRS) were computed using summary statistics from two recent...

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Identifiers

PMID: 37591043
DOI: 10.1016/j.drugalcdep.2023.110912
PMCID: PMC10638060

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