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Article

Cytoplasmatic compartmentalization by Bcr‐Abl promotes TET2 loss‐of‐function in chronic myeloid leukemia

3 Apr 2012

Abstract excerpt

The loss-of-function of ten-eleven-translocation (TET) 2, a Fe(2+) -oxoglutarate-dependent dioxygenase catalyzing 5 methyl cytosine (5mC) conversion into 5-hydroxymethylcytosine (5hmC), contributes to the hematopoietic transformation in vivo. The aim of our study was to elucidate its role in the phenotype of chronic myeloid leukemia (CML), a myeloproliferative disease caused by the Bcr-Abl rearranged gene. We...

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PMID: 22467095
DOI: 10.1002/jcb.24154

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