Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin.

Nature neuroscience - 1 May 2012

Lo Sardo Valentina, Zuccato Chiara, Gaudenzi Germano, Vitali Barbara, Ramos Catarina, Tartari Marzia, Myre Michael A, Walker James A, Pistocchi Anna, Conti Luciano, Valenza Marta, Drung Binia, Schmidt Boris, Gusella James, Zeitlin Scott, Cotelli Franco, Cattaneo Elena

Abstract excerpt

The Huntington's disease gene product, huntingtin, is indispensable for neural tube formation, but its role is obscure. We studied neurulation in htt-null embryonic stem cells and htt-morpholino zebrafish embryos and found a previously unknown, evolutionarily recent function for this ancient protein. We found that htt was essential for homotypic interactions between neuroepithelial cells; it permitted neurulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Ventricles
Share to Dipeptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanylate Kinases

Share to Hydroxamic Acids

Share to Nestin

Share to NFI Transcription Factors

Share to PAX2 Transcription Factor

Share to Tissue Inhibitor of Metalloproteinase-1

Source

Identifiers

PMID: 22466506
DOI: 10.1038/nn.3080

Genes

ADAM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin.PMID 22466506Read ↗

T-cadherin structures reveal a novel adhesive binding mechanism.Semantic proximity Read ↗

The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtinSemantic proximity Read ↗

Molecular genetics of neuronal recognition in Drosophila: evolution and function of immunoglobulin superfamily cell adhesion molecules.Semantic proximity Read ↗

The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafishSemantic proximity Read ↗

The secreted AdamTS-A metalloprotease is required for collective cell migration.Semantic proximity Read ↗

The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system.Semantic proximity Read ↗

Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination.Semantic proximity Read ↗

Adhesion properties and retinofugal expression of chicken protocadherin-19.Semantic proximity Read ↗

Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration.Semantic proximity Read ↗

Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.Semantic proximity Read ↗

Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development.Semantic proximity Read ↗

The cleavage of N-cadherin is essential for chondrocyte differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.