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Article

The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin

1 Dec 2020

Abstract excerpt

BACKGROUND: The huntingtin-associated protein 40 (HAP40) abundantly interacts with huntingtin (HTT), the protein that is altered in Huntington's disease (HD). Therefore, we analysed the evolution of HAP40 and its interaction with HTT. RESULTS: We found that in amniotes HAP40 is encoded by a single-exon gene, whereas in all other organisms it is expressed from multi-exon genes. HAP40 co-occurs with HTT in...

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PMID: 33297953
DOI: 10.1186/s12862-020-01705-5

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