Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system.

Development (Cambridge, England) - 1 Sept 2017

Skeath James B, Wilson Beth A, Romero Selena E, Snee Mark J, Zhu Yi, Lacin Haluk

Abstract excerpt

The extracellular matrix (ECM) regulates cell migration and sculpts organ shape. AdamTS proteins are extracellular metalloproteases known to modify ECM proteins and promote cell migration, but demonstrated roles for AdamTS proteins in regulating CNS structure and ensuring cell lineages remain fixed in place have not been uncovered. Using forward genetic approaches in Drosophila, we find that reduction of AdamTS-A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basement Membrane
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System

Share to Collagen Type IV

Share to Extracellular Matrix

Share to Integrin alpha Chains

Share to Neuroglia

Share to Subcellular Fractions

Source

Open in PubMed Open full text

Identifiers

PMID: 28760813
DOI: 10.1242/dev.145854
PMCID: PMC5611953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system.PMID 28760813Read ↗

Glia ECM interactions are required to shape the Drosophila nervous system.Semantic proximity Read ↗

The secreted AdamTS-A metalloprotease is required for collective cell migration.Semantic proximity Read ↗

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.Semantic proximity Read ↗

ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortexSemantic proximity Read ↗

Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology.Semantic proximity Read ↗

New Insights into ADAMTS Metalloproteases in the Central Nervous SystemSemantic proximity Read ↗

Organ Length Control by an ADAMTS Extracellular Protease in Caenorhabditis elegans.Semantic proximity Read ↗

ADAMTS proteins as modulators of microfibril formation and functionSemantic proximity Read ↗

ADAM proteins in the brainSemantic proximity Read ↗

Neural stem cells at the crossroads: MMPs may tell the waySemantic proximity Read ↗

Matrix metalloproteinases in neural development: a phylogenetically diverse perspectiveSemantic proximity Read ↗

Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and compromises extracellular matrix formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.