Article

Proton Pump Inhibitors and Cardiac Safety: Emerging Evidence Linking Cardiovascular Disease, Arrhythmias, and Mechanistic Pathways

2025-12-17

Abstract excerpt

Proton pump inhibitors (PPIs) are globally prescribed medications long perceived as pharmacologically safe. However, emerging evidence challenges this, revealing a potential association between chronic PPI exposure and adverse cardiovascular outcomes, including arrhythmogenesis. This review synthesizes findings from large, robust epidemiologic cohorts (ARIC, UK Biobank, Danish registries, Women’s Health Initiative...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 87fca540-2069-592f-8585-e39d36d2dda2
DOI: 10.22541/au.176598198.86224065/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proton Pump Inhibitors and Cardiac Safety: Emerging Evidence Linking Cardiovascular Disease, Arrhythmias, and Mechanistic PathwaysDOI 10.22541/au.176598198.86224065/v1Read

Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart DiseaseSemantic proximity Read

Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management.Semantic proximity Read

Cellular and ionic basis of J-wave syndromes.Semantic proximity Read

Heart Failure and Arrhythmias: Circadian and Epigenetic Interplay in Myocardial ElectrophysiologySemantic proximity Read

QT interval prolongation and cardiac risk assessment for novel drugs.Semantic proximity Read

Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models.Semantic proximity Read

Comprehensive preclinical evaluation of how cardiac safety profiles of potential COVID-19 drugs are modified by disease associated factors.Semantic proximity Read

Perioperative Arrhythmias: Pathophysiology, Risk Stratification, Management, and Emerging Technologies—A Narrative Review Toward Personalized CareSemantic proximity Read

French‐Speaking Network of Pharmacogenetics ( RNPGx ) Recommendations for Clinical Use of MavacamtenSemantic proximity Read

Proton Pump Inhibitors in Gastroesophageal Reflux Disease: Friend or Foe.Semantic proximity Read

hERG potassium channels and cardiac arrhythmia.Semantic proximity Read

[Functional impact of hERG: from physiological role to target of anticancer therapy].Semantic proximity Read