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Article

Insulin-like growth factor I receptor signaling and nuclear translocation of insulin receptor substrates 1 and 2.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2003

Sun HongZhi, Tu Xiao, Prisco Marco, Wu An, Casiburi Ivan, Baserga Renato

Abstract excerpt

The insulin receptor substrate 1 (IRS-1) can translocate to the nuclei and nucleoli of several types of cells. Nuclear translocation can be induced by an activated insulin-like growth factor 1 receptor (IGF-IR), and by certain oncogenes, such as the Simian virus 40 T antigen and v-src. We have asked whether IRS-2 could also translocate to the nuclei. In addition, we have studied the effects of functional...

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Identifiers

PMID: 12554758
DOI: 10.1210/me.2002-0276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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