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Article

Loss of HLTF function promotes intestinal carcinogenesis.

Molecular cancer - 27 Mar 2012

Sandhu Sumit, Wu Xiaoli, Nabi Zinnatun, Rastegar Mojgan, Kung Sam, Mai Sabine, Ding Hao

Abstract excerpt

BACKGROUND: HLTF (Helicase-like Transcription Factor) is a DNA helicase protein homologous to the SWI/SNF family involved in the maintenance of genomic stability and the regulation of gene expression. HLTF has also been found to be frequently inactivated by promoter hypermethylation in human colon cancers. Whether this epigenetic event is required for intestinal carcinogenesis is unknown. RESULTS: To address the...

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Source

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Identifiers

PMID: 22452792
DOI: 10.1186/1476-4598-11-18
PMCID: PMC3337324

Genes

HLTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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