Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.

doi:10.1074/jbc.274.32.22135

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Article

Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.

The Journal of biological chemistry - 6 Aug 1999

Poteet-Smith C E, Smith J A, Lannigan D A, Freed T A, Sturgill T W

Abstract excerpt

p90 ribosomal S6 kinases (RSKs), containing two distinct kinase catalytic domains, are phosphorylated and activated by extracellular signal-regulated kinase (ERK). The amino-terminal kinase domain (NTD) of RSK phosphorylates exogenous substrates, whereas the carboxyl-terminal kinase domain (CTD)...

Topics

Amino Acid Sequence
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Catalytic Domain
Cells, Cultured
Cricetinae
Enzyme Activation
Epidermal Growth Factor
Insulin
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Protein Structure, Secondary

Ribosomal Protein S6 Kinases

Ribosomes

Sequence Deletion

Sequence Homology, Amino Acid

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 10428774
DOI: 10.1074/jbc.274.32.22135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10428774-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.PMID 10428774Read ↗

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