Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.

The Journal of biological chemistry - 6 Aug 1999

Poteet-Smith C E, Smith J A, Lannigan D A, Freed T A, Sturgill T W

Abstract excerpt

p90 ribosomal S6 kinases (RSKs), containing two distinct kinase catalytic domains, are phosphorylated and activated by extracellular signal-regulated kinase (ERK). The amino-terminal kinase domain (NTD) of RSK phosphorylates exogenous substrates, whereas the carboxyl-terminal kinase domain (CTD) autophosphorylates Ser-386. A conserved putative autoinhibitory alpha helix is present in the carboxyl-terminal tail of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cricetinae

Share to Epidermal Growth Factor

Share to Insulin

Share to Protein Structure, Secondary

Share to Ribosomal Protein S6 Kinases

Share to Ribosomes

Source

Identifiers

PMID: 10428774
DOI: 10.1074/jbc.274.32.22135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.PMID 10428774Read ↗

Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases.Semantic proximity Read ↗

Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.Semantic proximity Read ↗

Functional Characterization of Human RSK4, a New 90-kDa Ribosomal S6 Kinase, Reveals Constitutive Activation in Most Cell TypesSemantic proximity Read ↗

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.Semantic proximity Read ↗

Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2).Semantic proximity Read ↗

p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cdelta.Semantic proximity Read ↗

Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.Semantic proximity Read ↗

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.Semantic proximity Read ↗

The C-terminal kinase and ERK-binding domains of Drosophila S6KII (RSK) are required for phosphorylation of the protein and modulation of circadian behavior.Semantic proximity Read ↗

14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.Semantic proximity Read ↗

Structural and functional analysis of pp70S6k.Semantic proximity Read ↗

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.