Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.

doi:10.1042/BJ20021794

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Article

Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1.

The Biochemical journal - 15 Jul 2003

Phin Sopheap, Kupferwasser Deborah, Lam Joseph, Lee-Fruman Kay K

Abstract excerpt

Ribosomal S6 kinase 2 (S6K2) is a serine/threonine kinase identified as a homologue of p70 ribosomal S6 kinase 1 (S6K1). S6K1 and S6K2 show different cellular localization as well as divergent amino acid sequences in non-catalytic domains, suggesting that their cellular functions and/or regulation may not be identical. Many of the serine/threonine residues that become phosphorylated and contribute to S6K1...

Topics

3-Phosphoinositide-Dependent Protein Kinases
Androstadienes
Antineoplastic Agents
Cells, Cultured
Humans
Immunosuppressive Agents
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Mutation

Phosphoinositide-3 Kinase Inhibitors

Phosphorylation

Precipitin Tests

Proline

Protein Serine-Threonine Kinases

Ribosomal Protein S6 Kinases, 90-kDa

Serine

Source

Open in PubMed Open full text

Identifiers

PMID: 12713446
DOI: 10.1042/BJ20021794
PMCID: PMC1223513

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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