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Article

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

Molecular neurodegeneration - 31 Oct 2011

Xifró Xavier, Anglada-Huguet Marta, Rué Laura, Saavedra Ana, Pérez-Navarro Esther, Alberch Jordi

Abstract excerpt

BACKGROUND: The 90-kDa ribosomal S6 kinase (Rsk) family is involved in cell survival. Rsk activation is regulated by sequential phosphorylations controlled by extracellular signal-regulated kinase (ERK) 1/2 and 3-phosphoinositide-dependent protein kinase 1 (PDK1). Altered ERK1/2 and PDK1 phosphorylation have been described in Huntington's disease (HD), characterized by the expression of mutant huntingtin (mhtt)...

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Source

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Identifiers

PMID: 22041125
DOI: 10.1186/1750-1326-6-74
PMCID: PMC3217046

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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