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Article

MC1R, ASIP, TYR, and TYRP1 gene variants in a population-based series of multiple primary melanomas.

Genes, chromosomes & cancer - 1 Jul 2012

Helsing Per, Nymoen Dag A, Rootwelt Helge, Vårdal Mari, Akslen Lars A, Molven Anders, Andresen Per A

Abstract excerpt

Allelic variants of the low-penetrance melanoma gene MC1R increase the risk of both melanoma and non-melanoma skin cancer. Common variants of the genes ASIP, TYR, and TYRP1, which regulate the melanogenic pathway, have also been shown to associate with melanoma. In this population-based study, we investigated SNPs of MC1R, ASIP, TYR, and TYRP1 as risk factors for development of multiple primary melanomas (MPM) in...

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Source

Identifiers

PMID: 22447455
DOI: 10.1002/gcc.21952

Genes

ASIP
TYR
TYRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MC1R, ASIP, TYR, and TYRP1 gene variants in a population-based series of multiple primary melanomas.PMID 22447455Read ↗

MC1R variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled analysis from the M-SKIP projectSemantic proximity Read ↗

ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma.Semantic proximity Read ↗

Melanocortin 1 receptor variants and their association with phenotypic characteristics and sporadic multiple primary melanomas in a cohort of 402 Spanish subjects.Semantic proximity Read ↗

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project.Semantic proximity Read ↗

A large French case-control study emphasizes the role of rare Mc1R variants in melanoma risk.Semantic proximity Read ↗

MC1R gene variants and non-melanoma skin cancer: a pooled-analysis from the M-SKIP project.Semantic proximity Read ↗

Inherited variation at MC1R and ASIP and association with melanoma-specific survival.Semantic proximity Read ↗

MC1R variation and melanoma risk in the Swedish population in relation to clinical and pathological parameters.Semantic proximity Read ↗

Melanocortin 1 receptor and risk of cutaneous melanoma: a meta-analysis and estimates of population burden.Semantic proximity Read ↗

Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations.Semantic proximity Read ↗

MC1R variants increase melanoma risk in families with CDKN2A mutations: a meta-analysis.Semantic proximity Read ↗

MC1R: three novel variants identified in a malignant melanoma association study in the Spanish population.Semantic proximity Read ↗

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