Article
MC1R variation and melanoma risk in the Swedish population in relation to clinical and pathological parameters.
Pigment cell & melanoma research - 1 Apr 2009
Höiom Veronica, Tuominen Rainer, Käller Max, Lindén Diana, Ahmadian Afshin, Månsson-Brahme Eva, Egyhazi Suzanne, Sjöberg Klas, Lundeberg Joakim, Hansson Johan
Abstract excerpt
The genetic background of cutaneous malignant melanoma (CMM) includes both germ line aberrations in high-penetrance genes, like CDKN2A, and allelic variation in low-penetrance genes like the melanocortin-1 receptor gene, MC1R. Red-hair colour associated MC1R alleles (RHC) have been associated with red hair, fair skin and risk of CMM. We investigated MC1R and CDKN2A variation in relation to phenotype, clinical...
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