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Article

Suppression of viral infectivity through lethal defection.

Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2005

Grande-Pérez Ana, Lázaro Ester, Lowenstein Pedro, Domingo Esteban, Manrubia Susanna C

Abstract excerpt

RNA viruses replicate with a very high error rate and give rise to heterogeneous, highly plastic populations able to adapt very rapidly to changing environments. Viral diseases are thus difficult to control because of the appearance of drug-resistant mutants, and it becomes essential to seek mechanisms able to force the extinction of the quasispecies before adaptation emerges. An alternative to the use of...

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Identifiers

PMID: 15767582
DOI: 10.1073/pnas.0408871102
PMCID: PMC555496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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