Article
Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1997
Chen K S, Nishimura M C, Armanini M P, Crowley C, Spencer S D, Phillips H S
Abstract excerpt
Administration of nerve growth factor (NGF) to aged or lesioned animals has been shown to reverse the atrophy of basal forebrain cholinergic neurons and ameliorate behavioral deficits. To examine the importance of endogenous NGF in the survival of basal forebrain cholinergic cells and in spatial...
Topics
- Acetylcholinesterase
- Alleles
- Animals
- Atrophy
- Behavior, Animal
- Hippocampus
- Injections, Intraventricular
- Maze Learning
- Memory Disorders
- Mice
- Mice, Mutant Strains
- Motor Activity
- Nerve Growth Factors
- Neurons
- Parasympathetic Nervous System
- Prosencephalon
- Septum Pellucidum
- Swimming