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Article

Hydroxyurea embryotoxicity is enhanced in P53-deficient mice.

Reproductive toxicology (Elmsford, N.Y.) - 1 Oct 2018

El Husseini Nazem, Hales Barbara F

Abstract excerpt

Hydroxyurea, a ribonucleotide reductase inhibitor, is a potent teratogen in mice, causing severe limb and skeletal defects. The exposure of gestation day nine murine embryos to hydroxyurea elicits an early embryonic stress response that involves activation of the P53 transcription factor. The impact of this P53 activation on the embryotoxicity of hydroxyurea- is not known. The goal of this study was to test the...

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Source

Identifiers

PMID: 29940331
DOI: 10.1016/j.reprotox.2018.06.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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