Article
The roles of p53 and p21 in normal development and hyperthermia-induced malformations.
Birth defects research. Part B, Developmental and reproductive toxicology - 1 Feb 2009
Hosako Hiromi, Francisco Liezl E, Martin Gail S, Mirkes Philip E
Abstract excerpt
BACKGROUND: Hyperthermia (HS) is a well-studied teratogen that induces serious malformations, including neural tube defects. Our previous studies have shown that HS induces apoptosis by activating the mitochondrial apoptotic pathway. Prior to activation of the mitochondrial apoptotic pathway, HS also activates p53 and its target genes. In the present study, we determine whether p53 and/or p21 play a role as...
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