Article
Apolipoprotein E-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016
Mehta Niyati U, Grijalva Victor, Hama Susan, Wagner Alan, Navab Mohamad, Fogelman Alan M, Reddy Srinivasa T
Abstract excerpt
OBJECTIVE: We previously reported that hemopexin (Hx), a heme scavenger, is significantly increased and associated with proinflammatory high-density lipoprotein under atherogenic conditions. Although it is established that Hx together with macrophages plays a role in mitigating oxidative damage, the role of Hx in the development of atherosclerosis is unknown. APPROACH AND RESULTS: We used Hx and apoE...
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