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Article

Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations.

Journal of virology - 17 Feb 2026

Schmierer Jordana, Lutz Michael, Takimoto Toru

Abstract excerpt

The 2009 pandemic H1N1 (pH1N1) influenza A virus (IAV) is a reassortant virus with two polymerase components, PA and PB2, originating from avian IAV. Avian IAV polymerase does not function efficiently in mammalian cells without host-adaptive mutations. The mechanism by which pH1N1 replicates in human hosts is not fully elucidated, as pH1N1 does not contain the host-adaptive PB2 E627K mutation required for...

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Source

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Identifiers

PMID: 41432626
DOI: 10.1128/jvi.01391-25
PMCID: PMC12911886

Genes

GRSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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