Article
Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition.
Thrombosis and haemostasis - 1 May 2012
Gebhard Cathérine, Holy Erik W, Camici Giovanni G, Akhmedov Alexander, Stämpfli Simon F, Stähli Barbara E, von Rickenbach Bettina, Breitenstein Alexander, Greutert Helen, Yang Zhihong, Lüscher Thomas F, Tanner Felix C
Abstract excerpt
Tissue factor (TF) is the key activator of coagulation and is involved in acute coronary syndromes. Caffeine is often reported to increase cardiovascular risk; however, its effect on cardiovascular morbidity and mortality is controversial. Hence, this study was designed to investigate the impact of caffeine on endothelial TF expression in vitro. Caffeine concentration-dependently enhanced TF protein expression...
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