Article
Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40.
Thrombosis and haemostasis - 1 Dec 1998
Slupsky J R, Kalbas M, Willuweit A, Henn V, Kroczek R A, Müller-Berghaus G
Abstract excerpt
CD40 is a type I member of the tumour necrosis factor (TNF) receptor superfamily of proteins, and is present on a wide variety of cells including vascular endothelial cells. Ligation of this receptor on endothelial cells is known to increase expression of inflammatory adhesion molecules. We have...
Topics
- Blood Platelets
- CD40 Antigens
- CD40 Ligand
- Cells, Cultured
- Endothelium, Vascular
- Free Radical Scavengers
- Gene Expression Regulation
- Hemostasis
- Humans
- Ligands
- Membrane Glycoproteins
- Phenotype
- Platelet Activation
- Pyrrolidines
- Thiocarbamates
- Thrombomodulin
- Thromboplastin
- Tumor Necrosis Factor-alpha