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Article

Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression.

Thrombosis and haemostasis - 1 Jun 2005

Görlach Agnes, BelAiba Rachida S, Hess John, Kietzmann Thomas

Abstract excerpt

The p21-activated serine/threonine kinases (PAK) play an important role in a variety of cellular functions. However, their role in the smooth muscle response to thrombin, which is activated upon vascular injury and promotes vascular remodelling processes, is not resolved. Here we investigated the role of PAK in thrombin signalling and regulation of tissue factor (TF), the activator of the extrinsic coagulation...

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Share to 3-Phosphoinositide-Dependent Protein Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

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Share to p38 Mitogen-Activated Protein Kinases

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Source

Identifiers

PMID: 15968404
DOI: 10.1160/TH05-01-0006

Genes

PDK1
PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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