Regulation of the Tissue Factor Gene

Abstract excerpt

Tissue factor is a cellular receptor that initiates blood coagulation. The TF gene is constitutively expressed in some extravascular cell types and is inducibly expressed in several vascular cell types, including monocytes, vascular endothelial cells and vascular smooth muscle cells. Functional studies indicate that Sp1 controls basal TF gene expression. A distal enhancer (-227 to -172) containing two AP-1 sites...

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