Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris.

doi:10.1038/jid.2012.46

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Article

Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris.

The Journal of investigative dermatology - 1 Jul 2012

Sarig Ofer, Bercovici Sivan, Zoller Lilach, Goldberg Ilan, Indelman Margarita, Nahum Sagi, Israeli Shirli, Sagiv Nadav, Martinez de Morentin Helena, Katz Oren, Baum Sharon, Barzilai Aviv, Trau Henri, Murrell Dedee F, Bergman Reuven, Hertl Michael, Rosenberg Shai, Nöthen Markus M, Skorecki Karl, Schmidt Enno, Zillikens Detlef, Darvasi Ariel, Geiger Dan, Rosset Saharon, Ibrahim Saleh M, Sprecher Eli

Abstract excerpt

Pemphigus vulgaris (PV) is a severe autoimmune blistering disease caused by anti-epithelial antibodies, leading to disruption of cell-cell adhesion. Although the disease is exceedingly rare worldwide, it is known to be relatively prevalent in Jewish populations. The low prevalence of the disease represents a significant obstacle to a genome-wide approach to the mapping of susceptibility genes. We reasoned that...

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PMID: 22437316
DOI: 10.1038/jid.2012.46

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