Article
Pemphigus vulgaris in Jewish patients is associated with HLA-A region genes: mapping by microsatellite markers.
Human immunology - 1 Aug 2003
Slomov Elena, Loewenthal Ron, Goldberg Ilan, Korostishevsky Michael, Brenner Sara, Gazit Ephraim
Abstract excerpt
Pemphigus vulgaris (PV) is the most severe autoimmune blistering disorder of the skin that is mediated by circulating autoantibodies against desmoglein 3 (Dsg3). It has been reported that in Jews the associated haplotype in PV is human leukocyte antigen (HLA) B38, DRB1*0402, DQB1*0302. Significant associations with HLA were observed also in non-Jews. Dsg3-specific T-cell responses were detected in PV patients but...
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