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Article

Genetic and immunological determinants of Pemphigus vulgaris: integrative analysis of HLA-DRB1 and FCGR2B variants.

Immunogenetics - 20 May 2026

Kasap Burak Kaan, Toraman Bayram, Kurt Burçin, Ermis Hande, Arıca Deniz Aksu

Abstract excerpt

Pemphigus vulgaris (PV) is a rare autoimmune blistering disease mediated by pathogenic autoantibodies. Although both HLA and non-HLA loci contribute to disease susceptibility, their combined roles in immune regulation remain incompletely understood. This study investigated the joint contribution of HLA-DRB1 and FCGR2B variants to PV susceptibility within an integrative immunogenetic framework. Genotype data from...

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Share to Alleles
Share to Epistasis, Genetic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HLA-DRB1 Chains

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 42156579
DOI: 10.1007/s00251-026-01402-5
PMCID: PMC13186795

Genes

FCGR2B

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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