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Article

Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function.

The international journal of biochemistry & cell biology - 1 Jun 2012

Chevrollier Arnaud, Cassereau Julien, Ferré Marc, Alban Jennifer, Desquiret-Dumas Valérie, Gueguen Naïg, Amati-Bonneau Patrizia, Procaccio Vincent, Bonneau Dominique, Reynier Pascal

Abstract excerpt

Mitochondria form dynamic tubular networks through processes of fission and fusion. Defect in mitochondrial dynamics lead to various pathologies, including several common and some rare neurodegenerative disorders. OPA1 and MFN2 are two key players in mitochondrial fusion associated with Autosomal Dominant Optic Atrophy and Charcot Marie Tooth neuropathy type 2A respectively. We used micropatterned coverslips to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22433900
DOI: 10.1016/j.biocel.2012.03.006

Genes

OPA1
MFN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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