Article
Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution.
Cell reports - 8 May 2018
Trevisan Tatiana, Pendin Diana, Montagna Aldo, Bova Sergio, Ghelli Anna Maria, Daga Andrea
Abstract excerpt
Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These processes govern mitochondria subcellular distribution, whose defects are emphasized in neurons because of their polarized structure. We have studied how perturbation of the fusion/fission balance affects mitochondria distribution in Drosophila...
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