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Article

[Clinical features of LRRK2-associated Parkinson's disease].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2011

Pchelina S N, Ivanova O N, Emel'ianov A K, Iakimovskiĭ A F

Abstract excerpt

Mutations in the Leucine Reach Repeat Kinase 2 (LRRK2) gene are the most frequent cause of familial Parkinson's disease (PD). Previously, we have sequenced the coding region of the LRRK2 gene in 85 PD patients and showed the prevalence of G2019S-associated PD (G2019S-PD) among all cases of LRRK2-associated PD in Russia. Screening of the most frequent LRRK2 mutations (G2019S, R1441C, R1441G) in the extended sample...

Topics

Aged
Aged, 80 and over
DNA Mutational Analysis
Female
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Levodopa
Male
Mutation
Parkinson Disease
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Protein Structure, Tertiary

Source

Identifiers

PMID: 22433811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22433811-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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[Clinical features of LRRK2-associated Parkinson's disease].PMID 22433811Read ↗

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