Article
[A PARK8 form of Parkinson's disease: a mutational analysis of the LRRK2 gene in Russian population].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2007
Shadrina M I, Illarioshkin S N, Bagyeva G Kh, Bespalova E V, Zagorodskaia T B, Slominskiĭ P A, Markova E D, Kliushnikov S A, Limborskaia S A, Ivanova-Smolenskaia I A
Abstract excerpt
A recently described form of Parkinson's disease - PARK8 - is caused by mutations in the novel LRRK2 gene on chromosome 12q12. The most common mutation in this gene is the substitution G2019S and we studied it for the first time in a large group of Russian Slavonic patients (311 patients) with Parkinson's disease including 295 sporadic and 16 familial cases. The mutation LRRK2-G2019S was identified in 1% of...
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