Article
[Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain].
Revista de neurologia - 16 May 2010
Morán José M, Castellanos-Pinedo Fernando, Casado-Naranjo Ignacio, Durán-Herrera Carmen, Ramírez-Moreno José M, Gómez Montserrat, Zurdo-Hernández José Martín, Fuentes Elisabet, Ortiz-Ortiz Miguel A, Moreno Antonio D, González-Polo Rosa A, Niso-Santano Mireia, Bravo-Sanpedro José M, Pérez-Tur Jordi, Ruiz-Mesa Luz M, Fuentes José M
Abstract excerpt
INTRODUCTION: LRRK2 mutations have been described as a common cause of Parkinson's disease (PD) in patients from northern Spain. Here we investigated the prevalence of these mutations in a cohort of Spanish PD patients (n = 96) from Extremadura, a region in southwestern Spain. SUBJECTS AND METHODS: To evaluate the rate of the G2019S and R1441G/C/H LRKK2 mutations in PD patients and healthy controls (n = 163)....
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