Article
G2019S LRRK2 mutation in familial and sporadic Parkinson's disease in Russia.
Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2006
Pchelina Sofya N, Yakimovskii Andrei F, Ivanova Olga N, Emelianov Anton K, Zakharchuk Andrei H, Schwarzman Alexander L
Abstract excerpt
Among mutations associated with autosomal dominant and sporadic Parkinson's disease (PD) the G2019S substitution in the leucine-rich repeat kinase 2 (LRRK2) gene is the most frequently identified. To estimate its frequency in Russia, we analyzed 208 patients with PD from the Northwestern region of Russia. Of these, 51 patients were probands from families with PD compatible with autosomal dominant inheritance. The...
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