Article
Identification of the translation start site of the human melanocortin 3 receptor.
Obesity facts - 1 Jan 2012
Tarnow Patrick, Rediger Anne, Schulz Angela, Grüters Annette, Biebermann Heike
Abstract excerpt
BACKGROUND: The melanocortin-3-receptor (MC3R) is a G-protein coupled receptor participating in hypothalamic energy metabolism. So far, it was assumed that the translation of the human MC3R starts at the non-conserved first ATG, however, a second evolutionary conserved ATG is located 37 amino acids downstream. One frequent polymorphism, T6K, is located between these two ATGs. METHODS: For characterization of the...
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