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Article

Effect of mRNA secondary structure on the efficiency of translational initiation by eukaryotic ribosomes.

European journal of biochemistry - 17 Aug 1990

Roy P, Rondeau S B, Vézina C, Boileau G

Abstract excerpt

We have used site-directed mutagenesis to determine whether the structural context surrounding the AUG triplet influences its ability to be selected as an initiation codon by the eukaryotic preinitiation complex. AUG triplets were introduced in a loop and stem structure naturally occurring at the midpoint of the 129-nucleotides-long 5'-untranslated region of the porcine proopiomelanocortin mRNA; one AUG triplet...

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PMID: 2167849
DOI: 10.1111/j.1432-1033.1990.tb19170.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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