Article
Effect of mRNA secondary structure on the efficiency of translational initiation by eukaryotic ribosomes.
European journal of biochemistry - 17 Aug 1990
Roy P, Rondeau S B, Vézina C, Boileau G
Abstract excerpt
We have used site-directed mutagenesis to determine whether the structural context surrounding the AUG triplet influences its ability to be selected as an initiation codon by the eukaryotic preinitiation complex. AUG triplets were introduced in a loop and stem structure naturally occurring at the...
Topics
- Animals
- Base Sequence
- Cell Line
- Codon
- DNA
- DNA Restriction Enzymes
- Haplorhini
- Kidney
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Peptide Chain Initiation, Translational
- Pro-Opiomelanocortin
- Promoter Regions, Genetic
- RNA, Messenger
- Ribosomes
- Swine
- Transcription, Genetic