Evidence indicating that the TM4, EL2, and TM5 of the melanocortin 3 receptor Do not participate in ligand binding.

doi:10.1006/bbrc.1996.1866

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Article

Evidence indicating that the TM4, EL2, and TM5 of the melanocortin 3 receptor Do not participate in ligand binding.

Biochemical and biophysical research communications - 24 Dec 1996

Schiöth H B, Muceniece R, Szardenings M, Prusis P, Wikberg J E

Abstract excerpt

The TM4, EL2 and TM5 show low amino acid homology within the MC receptor family. Three mutants of the human MC3 receptor were created in order to investigate the participation of these regions in ligand binding. The TM4, EL2 and TM5 were separately changed by multiple mutagenesis so that their am...

Topics

Animals
Binding Sites
COS Cells
Gene Transfer Techniques
Humans
Ligands
Mutation
Radioligand Assay
Receptor, Melanocortin, Type 3
Receptors, Corticotropin

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