Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of a C-terminal splice variant of the human melanocortin 1 receptor.

Experimental dermatology - 1 Jul 2020

Martínez-Vicente Idoya, Abrisqueta Marta, Herraiz Cecilia, Jiménez-Cervantes Celia, García-Borrón Jose Carlos, Olivares Concepción

Abstract excerpt

The melanocortin 1 receptor (MC1R) is a major determinant of skin pigmentation and sensitivity to ultraviolet radiation. When stimulated by its natural agonists, it promotes the switch from synthesis of poorly photoprotective and lightly colored pheomelanins to production of photoprotective and darker eumelanins. In addition to an unusually high number of single nucleotide polymorphisms, the MC1R is expressed as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Arrestin 2
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to HEK293 Cells

Share to MAP Kinase Signaling System

Share to Protein Isoforms

Share to Receptor, Melanocortin, Type 1

Share to Ubiquitination

Source

Identifiers

PMID: 32474972
DOI: 10.1111/exd.14118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of a C-terminal splice variant of the human melanocortin 1 receptor.PMID 32474972Read ↗

Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients.Semantic proximity Read ↗

Variant amino acids in different domains of the human melanocortin 1 receptor impair cell surface expression.Semantic proximity Read ↗

Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer.Semantic proximity Read ↗

Dimerization of the human melanocortin 1 receptor: functional consequences and dominant-negative effects.Semantic proximity Read ↗

Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi.Semantic proximity Read ↗

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.Semantic proximity Read ↗

Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.Semantic proximity Read ↗

Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells.Semantic proximity Read ↗

Identification and functional characterization of natural human melanocortin 1 receptor mutant alleles in Pakistani population.Semantic proximity Read ↗

Structural determinants regulating cell surface targeting of melanocortin receptors.Semantic proximity Read ↗

Melanocortin-1 receptor (MC1R): a review for dermatologists.Semantic proximity Read ↗

The melanocortin-1 receptor gene polymorphism and association with human skin cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.