Article
Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study.
Human molecular genetics - 1 Jan 2011
Murray Anna, Bennett Claire E, Perry John R B, Weedon Michael N, Jacobs Patricia A, Morris Danielle H, Orr Nicholas, Schoemaker Minouk J, Jones Michael, Ashworth Alan, Swerdlow Anthony J
Abstract excerpt
Women become infertile approximately 10 years before menopause, and as more women delay childbirth into their 30s, the number of women who experience infertility is likely to increase. Tests that predict the timing of menopause would allow women to make informed reproductive decisions. Current predictors are only effective just prior to menopause, and there are no long-range indicators. Age at menopause and early...
Topics
- Adult
- Age Factors
- Alleles
- Cell Cycle Proteins
- Female
- Genome-Wide Association Study
- Humans
- Menopause, Premature
- Middle Aged
- Minichromosome Maintenance Proteins