Article

Rare coding variants in five DNA damage repair genes associate with timing of natural menopause

2021-04-20

Abstract excerpt

The age of menopause is associated with fertility and disease risk, and its genetic control is of great interest. We used whole-exome sequences from 119,992 women in the UK Biobank to test for associations between rare damaging variants and age at natural menopause. Rare damaging variants in three genes significantly associated with menopause: CHEK2 (p = 6.2 × 10 −51 ) and DCLRE1A (p = 1.2 × 10 −12 ) with later me...

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Literature Corpus work: b8bde2d6-e989-52c0-87a7-291740c2e30c
DOI: 10.1101/2021.04.18.21255506

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